Yes, it is generally safe to use salicylic acid in the morning and Differin (adapalene) at night, as long as your skin tolerates both products well. However, it's important to note that these are both potent ingredients and can be drying or irritating for some individuals, especially when used together. It's always recommended to start with a lower concentration of each product and gradually increase if needed, while monitoring your skin's response.

Salicylic acid is a beta-hydroxy acid (BHA) that helps exfoliate the skin, unclog pores, and reduce acne. It is oil-soluble and works well for oily or acne-prone skin types. It is often found in cleansers, toners, and spot treatments.

Differin (adapalene) is a retinoid that helps regulate skin cell turnover, reduce inflammation, and prevent acne. It is commonly used to treat acne and can help improve overall skin texture and tone. It is usually applied as a thin layer at night, after cleansing and moisturizing.

When using both salicylic acid and Differin, it's essential to moisturize your skin adequately, as these ingredients can be drying. Additionally, always wear sunscreen during the day, as both salicylic acid and retinoids can increase skin sensitivity to the sun. If you experience excessive dryness, irritation, or any other adverse effects, it's best to consult with a dermatologist.