Yes, setting sprays can expire. Like any other beauty product, setting sprays have a shelf life and can lose their effectiveness over time. The expiration date of a setting spray can vary depending on the brand and formulation. It is typically indicated on the packaging or bottle. Using an expired setting spray may not provide the desired results, and it could potentially cause skin irritation or other adverse reactions. It's important to check the expiration date and replace your setting spray accordingly to ensure optimal performance and safety.