As an AI language model, I can provide some general information, but it's always best to consult with a dermatologist or healthcare professional for personalized advice.

Niacinamide is generally considered safe to use while on Accutane (isotretinoin) treatment. Niacinamide is a form of vitamin B3 that offers various benefits for the skin, including regulating sebum production, reducing inflammation, and improving the skin's barrier function.

Accutane is a potent medication used to treat severe acne, and it can cause dryness, sensitivity, and other side effects. Niacinamide can help mitigate some of these side effects by improving skin barrier function and reducing inflammation.

However, it's important to note that everyone's skin is different, and individual reactions may vary. It's always advisable to consult with a dermatologist or healthcare professional who can assess your specific situation and provide personalized recommendations.

Additionally, it's crucial to follow the guidance of your healthcare provider regarding the use of any skincare products or supplements while on Accutane treatment. They can provide the most accurate information based on your medical history and the specific details of your treatment plan.