Yes, it is generally safe to use azelaic acid in the morning and adapalene at night. Azelaic acid is a multifunctional ingredient that has anti-inflammatory and anti-bacterial properties, making it effective in treating acne and reducing redness. Adapalene, on the other hand, is a retinoid that helps to regulate skin cell turnover and reduce acne formation.

Using azelaic acid in the morning can help to control inflammation and bacteria throughout the day, while adapalene at night can work to exfoliate the skin and promote cell turnover. However, it is important to note that both of these ingredients can cause some initial skin irritation, so it is advisable to start with a lower concentration and gradually increase as tolerated.

Additionally, it is crucial to wear sunscreen during the day as both azelaic acid and adapalene can increase skin sensitivity to the sun. Regular use of sunscreen will help protect your skin from harmful UV rays and prevent any potential damage.