Yes, it is generally safe to use benzoyl peroxide with niacinamide and hyaluronic acid. However, it is important to keep in mind a few points:

1. Start with a lower concentration: When combining these ingredients for the first time, it is recommended to start with lower concentrations of each product to minimize the risk of skin irritation or sensitivity.

2. Patch test: Before applying any new combination of products to your entire face, perform a patch test on a small area of skin to check for any adverse reactions. This will help you determine if your skin tolerates the combination well.

3. Apply benzoyl peroxide first: If you are using all three ingredients in your skincare routine, apply benzoyl peroxide first. Benzoyl peroxide is an effective acne-fighting ingredient that can be drying and may cause some irritation. Applying it first allows it to penetrate the skin and target acne-causing bacteria before applying the other products.

4. Give time between applications: After applying benzoyl peroxide, wait for a few minutes to allow it to fully absorb into the skin before applying niacinamide and hyaluronic acid. This will help minimize any potential interaction between the ingredients.

5. Moisturize adequately: Benzoyl peroxide can be drying, so it is important to moisturize your skin well after applying it. Hyaluronic acid can help with hydration, and niacinamide can also provide some moisturizing benefits. Applying a moisturizer after these ingredients can help maintain the skin's moisture balance.

Remember, individual skin types and sensitivities can vary, so it is always a good idea to consult with a dermatologist or skincare professional if you have any concerns or specific skin conditions.