Yes, Panthenol can be used with Retinol. Panthenol, also known as Provitamin B5, is a moisturizing ingredient that helps to improve the skin's barrier function and hydration levels. It is well-tolerated by most skin types and is considered safe for use.

Retinol, on the other hand, is a derivative of Vitamin A and is widely used in skincare for its anti-aging benefits. It helps to stimulate collagen production, improve skin texture, and reduce the appearance of fine lines and wrinkles.

When used together, Panthenol and Retinol can complement each other's effects on the skin. Retinol can sometimes cause dryness or irritation, especially when used in higher concentrations or by individuals with sensitive skin. Panthenol can help to counteract these potential side effects by providing hydration and soothing the skin.

To use both ingredients together, it is recommended to apply Retinol first, allowing it to fully absorb into the skin, and then follow with a moisturizer containing Panthenol. This will help to maximize the benefits of both ingredients while minimizing any potential irritation. It is also important to note that individuals with extremely sensitive skin may still experience some level of irritation, so it is always advisable to start with lower concentrations and gradually increase usage as tolerated.