Yes, it is generally safe to use azelaic acid with adapalene. Both azelaic acid and adapalene are commonly used in the treatment of acne and have complementary mechanisms of action.

Azelaic acid is a naturally occurring dicarboxylic acid that has anti-inflammatory and antimicrobial properties. It helps to reduce the production of keratin, which can clog pores and contribute to the formation of acne. Azelaic acid also has a mild exfoliating effect, helping to unclog pores and fade post-inflammatory hyperpigmentation.

Adapalene is a retinoid that works by normalizing the differentiation of skin cells and reducing inflammation. It helps to prevent the formation of comedones (clogged pores) and promotes the turnover of skin cells, preventing the buildup of dead skin cells that can contribute to acne.

When used together, azelaic acid and adapalene can provide a more comprehensive treatment approach for acne. Azelaic acid can help to reduce inflammation and fade post-inflammatory hyperpigmentation, while adapalene helps to prevent the formation of new acne lesions and promote skin cell turnover.

However, it is important to note that everyone's skin is different, and some individuals may experience skin irritation or sensitivity when using both azelaic acid and adapalene together. It is always recommended to start with a lower concentration of each ingredient and gradually increase the frequency of use to allow your skin to adjust. If you experience any excessive dryness, redness, or irritation, it is best to consult with a dermatologist for personalized advice.